Abstract: The preliminary design for the bioconversion of 1,3-propanediol from glycerol with annual production capacity of 1000 tons was achieved by three separation processes operated sequentially，which were an aqueous two-phase extraction，an alcohol precipitation and an electrodialysis．The process simulation software，ProⅡ，was used to simulate the three downstream processes．Based on energy and material balance，the raw material，utilities and equipments costs of these three processes were calculated．The cost analysis indicated that the total costs of alcohol precipitation，aqueous two-phase extraction and electrodialysis were 14793，14201 and 14345（RMB/t），respectively．The economic sensitivity analysis showed that the price of glycerol was the key factor influencing the unit costs．The increasing of the concentration and yield of 1,3-propanediol will help to reduce production costs and improve process economic efficiency．

Key words: 1,3-propanediol, separation processes, process simulation, production cost, sensitivity analysis

摘要： 对以甘油为原料微生物法年产千吨1,3-丙二醇的3种分离工艺流程（醇沉、双水相、电渗析）进行了初步设计，并采用化工流程模拟软件Pro Ⅱ进行了模拟，依据所得之能耗和物料平衡数据计算了不同工艺的原料成本、运行成本和设备成本。结果表明，醇沉、双水相和电渗析三种工艺的总生产成本分别为14793 ¥/t、14201 ¥/t和14345 ¥/t。敏感性分析表明，甘油价格是影响工艺单位成本的最关键因素；提高1,3-丙二醇浓度和转化率，有利于降低生产成本，提高工艺的经济性。

关键词: 3-丙二醇, 分离工艺, 流程模拟, 生产成本, 敏感性分析, separation processes, process simulation, production cost, sensitivity analysis, 1,3-丙二醇, 分离工艺, 流程模拟, 生产成本, 敏感性分析